Cardiovascular disease (CVD) is one of the leading causes of death worldwide which is more prevalent in women after menopause. Hormonal changes associated with menopause are accountable for dyslipidemic pattern that causes CVD and associated complications. Therefore, the present study was commenced to compare the lipid profile in pre- and postmenopausal women. A descriptive cross-sectional study was conducted at Manmohan Memorial Institute of Health Sciences (MMIHS) from February 2016 to July 2016. A total of 260 fasting samples were collected from healthy women, 130 from premenopausal and 130 from postmenopausal women, and analyzed for Total Cholesterol (TC), Triacylglycerol (TAG), High Density Lipoprotein Cholesterol (HDL-C), and Low Density Lipoprotein Cholesterol (LDL-C) as per the guideline provided by the reagent manufacturer (Human, Germany). All the parameters were analyzed by Stat Fax 3300 semi auto analyzer. TC, TAG, HDL-C, and LDL-C were highly significantly increased in postmenopausal women when compared to premenopausal women. LDL/HDL ratio was significantly elevated in postmenopausal women than in premenopausal women. BMI was significantly positively correlated with TC and TAG in both pre- and postmenopausal population and it was positively correlated with HDL-C in premenopausal population while negatively correlated in postmenopausal population. Since more of the atherogenic lipid parameters are increased in postmenopausal women, they appear to be more prone to have CVD and associated complications in near future. Hence, it is mandatory to monitor and manage dyslipidemic pattern in every woman experiencing menopause.
Stat Fax 3300 Pdf 22
The study was carried out in 260 healthy women; among them 130 were premenopausal and 130 were postmenopausal. The average age of premenopausal group was 35.96 8.6 and that of postmenopausal group was 64.5 11.1. Serum TC, TAG, HDL-C, and LDL-C levels were found to be statistically significantly increased in postmenopausal women compared to premenopausal women ( value
The atherogenic indices TC/HDL and TAG/HDL were found to be increased but not significantly in postmenopausal women compared to premenopausal women. However, LDL/HDL ratio was found to be statistically significantly increased in postmenopausal women than in premenopausal women. We found that 18.4% of postmenopausal women were under cardiovascular risk as defined by TC/HDL indices greater than 5 (Table 2).
A longitudinal study done by Derby et al. showed increasing trend of TC from premenopausal through menopausal transition to postmenopausal status [16]. Though various factors influencing cholesterol are prevalent, most detrimental cause of increase in TC level in postmenopausal women could be alteration in the cardioprotective sex hormone especially estrogen and progesterone. Also some studies have revealed the occurrence of great genetic variance for most lipids [3].
Limitations. This study was time framed study, conducted during the period of six months in a community of Lalitpur, Nepal, which limits the sample size to establishing causality of this descriptive cross-sectional study. This study could not give definite range of age group in both pre- and postmenopausal groups as samples were collected randomly from the specific community. In addition, the study also limits establishing the relation of cardiovascular risk with the social status of study population.
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